Journal of Movement Disorders

Original Articles

Cognition, Olfaction and Uric Acid in Early de novo Parkinson’s Disease: Hwa Reung Lee, Joong Hyun Park, Sang Won Han, Jong Sam Baik; J Mov Disord. 2018;11(3):139-144. Published online September 30, 2018; DOI: https://doi.org/10.14802/jmd.18037

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Objective
Cognitive impairment is one of the nonmotor symptoms in Parkinson’s disease (PD), and olfactory dysfunction is used as a marker to detect premotor stages of PD. Serum uric acid (sUA) levels have been found to be a risk factor for PD. Our objective in this study was to examine whether sUA levels are associated with cognitive changes and olfactory dysfunction in early de novo PD patients.
Methods
The study participants included 196 de novo PD patients. We assessed cognitive function by the Korean versions of the Mini-Mental State Examination and the Montreal Cognitive Assessment and assessed olfactory function by the Korean version of the Sniffin’ Sticks test.
Results
The mean sUA level was 4.7 mg/dL and was significantly lower in women than in men. Cognitive scores were lower in women, suggesting that sUA levels were related to cognitive function. The olfactory functions were not related to sUA level but were clearly associated with cognitive scores. Olfactory threshold, odor discrimination, and odor identification were all significantly related to cognitive scores.
Conclusion
We conclude that lower sUA levels were associated with cognitive impairment, not olfactory dysfunction, in de novo PD patients. This finding suggests that UA is neuroprotective as an antioxidant in the cognitive function of PD patients.

Citations

Citations to this article as recorded by

Serum uric acid and Parkinson's disease: A systematic review and meta‐analysis
Mohammad Balabandian, Sarvenaz Salahi, Behnaz Mahmoudvand, Mahla Esmaeilzadeh, Seyedeh Melika Hashemi, Fardin Nabizadeh
Neurology and Clinical Neuroscience.2023; 11(6): 299. CrossRef
International consensus statement on allergy and rhinology: Olfaction
Zara M. Patel, Eric H. Holbrook, Justin H. Turner, Nithin D. Adappa, Mark W. Albers, Aytug Altundag, Simone Appenzeller, Richard M. Costanzo, Ilona Croy, Greg E. Davis, Puya Dehgani‐Mobaraki, Richard L. Doty, Valerie B. Duffy, Bradley J. Goldstein, David
International Forum of Allergy & Rhinology.2022; 12(4): 327. CrossRef
Association of serum uric acid and non-motor symptoms in Parkinson's disease: A cross-sectional study from a movement disorders clinic in Lagos, Nigeria
OlanikeA Odeniyi, OluwadamilolaO Ojo, IfedayoAdeola Odeniyi, NjidekaUlunma Okubadejo
Journal of Clinical Sciences.2022; 19(3): 104. CrossRef
A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson’s disease
Per Borghammer, Mie Kristine Just, Jacob Horsager, Casper Skjærbæk, Anna Raunio, Eloise H. Kok, Sara Savola, Shigeo Murayama, Yuko Saito, Liisa Myllykangas, Nathalie Van Den Berge
npj Parkinson's Disease.2022;[Epub] CrossRef
What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
Paola Tirassa, Tommaso Schirinzi, Marcello Raspa, Massimo Ralli, Antonio Greco, Antonella Polimeni, Roberta Possenti, Nicola Biagio Mercuri, Cinzia Severini
Neuroscience & Biobehavioral Reviews.2021; 131: 899. CrossRef
Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis
Per Borghammer, Nathalie Van Den Berge, Teus van Laar
Journal of Parkinson's Disease.2019; 9(s2): S281. CrossRef

A Comparative Study of Central Hemodynamics in Parkinson’s Disease: Joong Hyun Park, Sang Won Han, Jong Sam Baik; J Mov Disord. 2017;10(3):135-139. Published online August 31, 2017; DOI: https://doi.org/10.14802/jmd.17035

6,394 View
95 Download
3 Web of Science
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Abstract PDF

Objective
To explore the central aortic pressure in patients with Parkinson’s disease (PD).
Methods
We investigated central arterial stiffness by measurement of the augmentation index (AIx) in PD patients. Patients were eligible for the study if they were de novo PD and 45 years of age or older. The patients’ demographics, vascular risk factors, and neurologic examinations were collected at baseline. The AIx was measured by applanation tonometry.
Results
A total of 147 subjects (77 in control and 70 in PD groups) were enrolled in the study. While there was no significant difference in peripheral systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure between groups, peripheral pulse pressure (PP) was significantly lower in the PD group than in the control group (p = 0.012). Regarding central pressure, aortic DBP was significantly higher and PP was significantly lower in the PD group (p = 0.001, < 0.0001). Although there was no significant difference in the AIx between the groups, a trend toward a lower AIx was observed in the PD group (31.2% vs. 28.1%, p = 0.074).
Conclusion
This study showed that peripheral and central PP was significantly lower in the PD group than in the control group. Our study suggests that PD patients may have a low risk of a cardiovascular event by reason of a lower PP.

Citations

Citations to this article as recorded by

Central Aortic Pressure and Arterial Stiffness in Parkinson’s Disease: A Comparative Study
Mehmet Balal, Meltem Demirkiran, Saime Paydas, Seyed-Mohammad Fereshtehnejad
Parkinson's Disease.2022; 2022: 1. CrossRef
Selected autonomic signs and symptoms as risk markers for phenoconversion and functional dependence in prodromal Parkinson’s disease
Cameron Miller-Patterson, Jesse Y. Hsu, Lana M. Chahine, James F. Morley, Allison W. Willis
Clinical Autonomic Research.2022; 32(6): 463. CrossRef
VEGF Signaling in Neurological Disorders
Joon Shim, Joseph Madsen
International Journal of Molecular Sciences.2018; 19(1): 275. CrossRef

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